Study takes step toward erasing bad memories

[Nostalgia]

LONDON, Feb 15 (Reuters) - A widely available blood pressure pill could one day help people erase bad memories, perhaps treating some anxiety disorders and phobias, according to a Dutch study published on Sunday.

The generic beta-blocker propranolol significantly weakened people's fearful memories of spiders among a group of healthy volunteers who took it, said Merel Kindt, a psychologist at the University of Amsterdam, who led the study.

"We could show that the fear response went away, which suggests the memory was weakened," Kindt said in a telephone interview.

The findings published in the journal Nature Neuroscience are important because the drug may offer another way to help people suffering from post-traumatic stress disorder and other problems related to bad memories.

Traditionally, therapists seek to teach people with such disorders strategies to build new associations and block bad memories. The problem, Kindt said, is the memories remain and people often relapse.

Animal studies have shown that fear memories can change when recalled, a process known as reconsolidation. At this stage they are also vulnerable to beta-blockers like propranolol, which target neurons in the brain, the researchers said.

Kindt and her team's experiment included 60 men and women who learned to associate pictures of spiders with a mild shock. This experience created a fearful memory, the researchers said.

Other participants saw the same picture but did not receive an electrical shock. For these people this established a "safe" association without a fear response or bad memory.

One day later people given the drug had a greatly decreased fear response compared with people on the placebo when shown the picture and given a mild shock, the researchers said.

"There was no difference to the fear spider and the safe spider," Kindt said. "This shows it is possible to weaken the underlying memory by interfering with it."

The next steps are to look at how long the drug's effects on memory last, and testing the treatment in people who actually are suffering from some kind of disorder or phobia, Kindt said. (Reporting by Michael Kahn; Editing by Maggie Fox and Elizabeth Piper)

http://www.zimbio.com/Reuters+Health...g+bad+memories

[Nostalgia]

Pill to erase bad memories: Ethical furore over drugs 'that threaten human identity'

A drug which appears to erase painful memories has been developed by scientists.

The astonishing treatment could help sufferers of post-traumatic stress disorder and those whose lives are plagued by hurtful recurrent memories.

But British experts said the breakthrough raises disturbing ethical questions about what makes us human.

They also warned it could have damaging psychological consequences, preventing those who take it from learning from their mistakes.

Dr Daniel Sokol, a lecturer in medical ethics at St George's, University of London, said: 'Removing bad memories is not like removing a wart or a mole. It will change our personal identity since who we are is linked to our memories.

'It may perhaps be beneficial in some cases, but before eradicating memories, we must reflect on the knock-on effects that this will have on individuals, society and our sense of humanity.'

Dutch researchers claim to have erased bad memories by using 'beta-blocker' drugs, which are usually prescribed to patients with heart disease.

The drug could erase frightening memories - such as spider phobia

The drug could erase frightening memories - such as spider phobia

Experiments on animals had already shown that the drugs - beta-adrenergic receptor blockers - can interfere with how the brain makes and remakes memories of frightening events.

In the latest study, Dr Merel Kindt of Amsterdam University tested the drugs on 60 men and women.

His team created fearful memories in volunteers by showing them pictures of spiders while giving them gentle electric shocks.

The volunteers were urged to 'actively remember' the images, creating a strong negative association between spiders and discomfort.

The following day the volunteers were split into two groups. One was given the beta blocker and the other a placebo pill before both were shown the same spider pictures.

The researchers recorded the level of fear in the volunteers by playing sudden noises and measuring how strongly they blinked.

A strong startle response showed they were in a fearful state, while a mild response showed they were calm.

The group given the beta blocker had a much weaker fear response than those given the dummy pill, the researchers report in the journal Nature Neuroscience.

A day later - once the drug was out of their systems - their fear response was tested again.

Once more, those given the beta blocker the previous day showed fewer signs of spider phobia, suggesting the memory was completely erased.

Beta blockers appear to work because each time someone recalls a powerful emotional memory the memory is 'remade' by the brain.



The drug interferes with this re-creation of the stressful memory - and prevents the brain renewing it.

In theory, it could eradicate memories of traumatic events that happened years ago. It might also help patients overcome phobias, obsessions, eating disorders and even sexual hang-ups.

Dr Kindt said: 'Traditionally, therapists seek to teach people with such disorders strategies to build new associations and block bad memories but the problem is the memories remain and people often relapse.'

It could be several years before doctors prescribe the drugs for patients with post-traumatic stress disorder.
Mahood cartoon

The scientists say more tests are needed to confirm the drug's memory- erasing properties. Dr Kindt said: 'The next steps are to look at how long the drug's effects on memory last, and testing the treatment in people who actually are suffering from some kind of disorder or phobia.'

But British experts warned the drug raises some difficult questions.

Professor John Harris, an expert in biological ethics at the University of Manchester, said: 'It is obviously up to the individual whether or not she wishes to risk the possible effects, including psychological discontinuity, of erasing unpleasant memories.

'An interesting complexity is the possibility that victims, say of violence, might wish to erase the painful memory and with it their ability to give evidence against assailants.

'Similarly criminals and witnesses to crime may, under the guise of erasing a painful memory, render themselves unable to give evidence.'

Paul Farmer, chief executive of the mental-health charity Mind, said he was concerned about the 'fundamentally pharmacological' approach to problems such as phobias and anxiety.

He told Channel 4 News that the unintended consequences 'could include the eradication of positive memories'.

Professor Neil Burgess of the Institute of Cognitive Neuroscience told the programme that wide-scale use of the drug was a long way off.

'All they've shown so far is that the increased ability to startle someone if they are feeling a bit anxious is reduced,' he said.

The ability to remove memories has been the stuff of science fiction for decades.

In the film Eternal Sunshine of the Spotless Mind, which starred Kate Winslet and Jim Carrey, a couple used a technique to erase memories of each other when their relationship turned sour.

http://www.dailymail.co.uk/news/arti...-identity.html

[Regina]

Was going to say that this reminds of Eternal Sunshine of the Spotless Mind - awesome film! Go and watch it if you haven't seen it.

There is an alternative process without the use of man-made drugs, which is explained in my book that was published in August 2008. I have named the process as the Self-Development Eradication Process (S.D.E.P). This is actually a part of evolution that is yet unknown. It explains how and why this process is part of a bigger picture. It is part of Love Indemnifying For Evolution (LIFE). Please visit www.s-dep.com for further information regarding the book.