The remarks come as Israeli strikes on Gaza entered a fifth day, without an end in sight to the largest assault on the beleaguered strip in decades.
Iran's President Mahmoud Ahmadinejad said on Tuesday that the fierce Israeli air assault on Gaza, which "aims to root out Hamas and the Palestinians", would only lead to the "disintegration of the Israeli regime".
Facing growing international pressure, Israel's top leaders have so far rejected the idea of a temporary ceasefire.
Israel is also massing its gunboats near the Gaza port and its ground forces along the border with Gaza in preparation for a possible ground offensive.
Earlier on Monday, a senior Iranian commander floated the idea that the time has come for Muslims to militarily stop Israeli crimes in Gaza.
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